Fibroids And Estrogen: What Hormone Causes Uterine Fibroids to Grow?

Fibroids and Estrogen: Are Fibroids Affected by Hormones?

After being diagnosed with uterine fibroids women often hear or read about the dependence of these benign tumors and hormones. Fibroids and estrogen: what is the relationship between them? And how can this knowledge help in preventing/curtailing symptoms from the fibroids?

Fibroids can cause many problems for women which worsen their quality of life. Long, heavy, and painful menstruation and uterine bleeding can contribute to the development of anemia; hemoglobin levels drop, weakness takes over, fatigue, dizziness, shortness of breath, decreased performance, loss of appetite, and many other symptoms become apparent. Large fibroids can lead to significant pelvic pain and/or pressure and impaired functions of neighboring organs (e.g. bladder, bowel) as well and even affect fertility. Frequent urination, waking multiple times at night to urinate, leaking urine, constipation and/or painful bowel movements, and painful sex, all are possible symptoms of fibroids.

Does Estrogen Cause Uterine Fibroids to Grow?

While no one knows where fibroids come from, it has been shown that they are sensitive to hormones; notably estrogen and progesterone. An imbalance of these hormones can seriously affect women’s health. Each of these hormones is directly related to the development of reproductive organs, so it is extremely important to maintain their balance to ensure a productive and healthy life.

It is also true that changes in estrogen and progesterone levels can affect fibroid growth. These are the two most important hormones in the female body that are produced by the ovaries. They are vital for normal reproductive development and fertility.

  • Estrogen, a steroid hormone, carries physiological messages to the uterus to grow and replace the lining that is shed during menses.
  • Progesterone helps regulate menstruation, prepares the body for pregnancy, and aids in nourishing the uterine environment to support the implantation of a fertilized egg as well as the growth of the placenta.

When estrogen levels are too high, this can lead to the growth of fibroid tumors, and with insufficient progesterone, the body has no way to stop this growth. Progesterone not only limits the effect of estrogen on fibroids but can also inhibit the growth and decrease the size of fibroids in some cases.

Sometimes, with elevated estrogen, hormone therapy with progesterone can help stop the pain and growth of fibroids. However, it is intended only to relieve the symptoms and stop fibroid growth temporarily. This will not cure fibroids but only slow their development. However, with progesterone therapy, many women experience side effects ranging from weight gain to insomnia and fatigue. Because of this, progesterone therapy is recommended as a temporary solution before the proper treatment of fibroids.

Hormonal treatment of fibroids is generally more effective in women with small fibroids and is less likely to be successful in women with multiple or large fibroids. If you are currently looking for an effective fibroid treatment, progesterone therapy usually is not enough.

In addition to hormonal therapy, estrogen levels (and the growth of fibroids to a degree) can be controlled through a low-estrogen diet. There are foods that should be limited or excluded from your diet like margarine, butter mixes, butter; fatty meats (and processed meats); smoked products; hard cheeses with a high percentage of fat, processed cheeses, sausage cheeses; muffins and pastries (and other white flour products); sweets, including ice creams, cakes, fudge, sodas, and other sugary foods. While overall alcohol consumption should be limited, red wine in moderation is actually beneficial. This is due to flavonoids in red wine which block estrogen production (as an aside, these compounds are also found in colored fruits and vegetables and dark chocolate). Green tea extract (EGCG) has also been shown to help with fibroid symptoms by reducing fibroid size.

In addition, proper nutrition can increase progesterone levels. Vegetable fats are needed to produce progesterone: avocados, coconut oil, olives, red peppers, raspberries, and nuts; products containing vitamin P and ascorutin like citrus fruits, and black currant; beta carotene-rich foods. Eggs, poultry, poultry, and fish are also beneficial. For cooking, use turmeric, a mixture of curry, thyme, and oregano.

Uterine Fibroid Embolization in Atlanta, GA

FAQs About The Relationship Between Fibroids And Hormones

Hormones that are out of balance can cause or exacerbate many gynecological conditions faced by women. We know that there is a link between estrogen and fibroids and progesterone and fibroids; however, there is often confusion about how this relationship works. We have answered some of the questions we receive most often about fibroids and hormones.

Does progesterone shrink fibroids?

Research on this subject has not concluded that progesterone is effective in shrinking fibroids. We know that progesterone helps to balance out estrogen which can help improve symptoms.

One researcher from Brussels, Belgium, conducted a review study of many research papers that had been written on the subject and found that these studies reported that there was insufficient evidence to support the theory that using progesterone would shrink fibroids and just added fuel to the fire (due to side effects) Overall progesterone for shrinking fibroids was ruled ineffective.

Do fibroids produce hormones?

The findings of research done by the Feinberg School of Medicine at Northwestern University and published in the National Library of Medicine in August 2015 revealed that fibroids not only react to estrogen that is present in the bloodstream but are capable of producing enough of their own estrogen to sustain themselves.

Do fibroids affect hormones or cause hormonal imbalances?

Hormone imbalances can have an effect on fibroids, but these benign growths do not affect a woman’s hormones. Other conditions, such as PCOS (polycystic ovary syndrome), can create an imbalance in hormone levels, and it is possible for a woman to deal with both conditions at the same time.

Treatment Options for Uterine Fibroids

Today there are several ways to treat fibroids that allow a woman to keep her uterus. One of them is myomectomy, a surgery to remove a percentage of the fibroid tumors. However, after this procedure, there are typically several living fibroids still inside the uterus. These fibroids will ultimately grow, and therefore, within 5 years over half of the women treated with myomectomy will need another procedure (over 1/3 of them within 3 years.). Also, every woman who intends to undergo a myomectomy has to sign a waiver/release stating she’s aware that she may wake up without her uterus.

The safer, less invasive, and more effective fibroid treatment option is uterine fibroid embolization (UFE). During this 30-40 minute nonsurgical procedure, small particles are introduced into the blood vessels that supply all of the fibroid tumors. Without a blood supply, all of the fibroids will start to die off. The death of all of the fibroids, causes them to soften and shrink, and as this occurs, the woman’s symptoms start to disappear. The death of all of the fibroids also means that for the vast majority of women who undergo UFE, it is the only procedure they will ever need (i.e. “one and done” unlike surgical myomectomy). This option is ideal for women who want to avoid the risks and long recovery of surgery and is even a consideration for women who want to maintain their fertility.

For more information on fibroids and UFE, make an appointment with Dr. John Lipman of Atlanta Fibroid Center by calling 770-214-4600 or make an appointment online.

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